![]() I know someone who is taking ablify at the age of fifteen for bipolar 1. Posted by: Tristan Hamilton at Novem09:25 PM Things were suppressed by Valium for a few days but when that wore off I had restless/involuntary movement disorders to a horrific degree. Immediately upon starting i I couldn't sit or lie down comfortably - I had to move. I had the worst experience of my life after taking Abilify for 13 days. Posted by: Matthew Forman at Novem12:37 AM I was treated with Inderal 80mg and xanax 1mg 4 x daily and the symptoms are now under control. I have also been taking Abilify for 13 months and was diagnosed with Akathisia 3 months ago due to the fact that I was vert restless and had shaking in my leg. Posted by: Joel Tegenkamp at Octo12:13 PM ![]() I cannot find comfort sitting, standing or laying down Things I used to do no longer bring about any form of contentment. Never have I felt so restless in my life. I've been taking Abilify now for a couple of months. MY WIFE HAD THE SAME SYMPTONS AND MORE AFTER ![]() Regardless, side effects like these are taken seriously and should be reported to a physician if they are noticed after starting any antipsychotic medication.Ĭohen S, Rulf D, Pies R: Extrapyramidal side effects associated with aripiprazole coprescription in 2 patients. It is also possible that the interaction with other medications may have prompted the side effect, or it could be something that is unique about these individuals. It is less frequent than with many other medications though. While it was theorized that these symptoms would be less of an issue with aripiprazole, because of the new mechanism of action described above, it is worth noting that these situations can still occur. However, this is a case report and therefore is merely one or two instances of this happening and not evidence of widespread problems. However, these things do happen and one should pay attention as one should when starting any new medicine. Generally, when started slowly, it is considered a safe drug though with little risk of severe side effects. What does this mean? Aripiprazole is still a new drug and we are learning about side effects with treatment. Of note, his symptoms continued even after lowering his dose to 5mg and also trying benztropine (Cogentin) which is a medicine that is often effective in treating EPS. His symptoms also resolved shortly after stopping the aripiprazole. The other patient had started 10mg of aripiprazole and shortly thereafter began having akathisia (severe restlessness such that a person feels like they are "crawling out of their skin"). Within one week of discontinuing the medication the symptoms resolved. In the first report, the patient developed Parkinsonian symptoms (shuffling gait, absence of facial expressions, pill-rolling tremor, stiffness) after being on 15mg aripiprazole for two days. Neither of these patients was considered psychotic or had schizophrenia, but the medication was used to try and target symptoms that were not responding to other, more conventional, therapies. One patient was started on aripiprazole to target symptoms of hypochondriasis (elevated and irrational feeling of being ill) and the other was started to target symptoms of obsessive-compulsive problems and severe depression. Two recent case reports have been published in which the authors describe patients that after starting aripiprazole, developing EPS. Aripiprazole is called a "partial dopamine agonist" that means that it theoretically increases the amount of dopamine in areas where it is too low (and perhaps causing movement disorders and stiffness) and decreases it where it is too high (and maybe causing hallucinations/delusions.) ![]() ![]() Extra-pyramidal symptoms are the typical side effects of antipsychotic medication that manifest as tremors, stiffness, shuffling gait, slow movements and/or severe restlessness (akathisia). It has a different mechanism than the other medications and for that reason there has been hope that it would have fewer problems with side effects. Schizophrenia Med Side-effectsĪripiprazole (Abilify) and Extra-pyramidal symptoms (EPS)Īripiprazole (Abilify) is the newest drug in the class of atypical antipsychotics. ![]()
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